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Quick update: Procalcitonin-guided cessation of Rx may be beneficial

Systematic Review and Meta-Analysis of Procalcitonin-Guidance Versus Usual Care for Antimicrobial Management in Critically Ill Patients: Focus on Subgroups Based on Antibiotic Initiation, Cessation, or Mixed Strategies

  • Procalcitonin may be used to shorten the duration of Rx in patients with sepsis

  • Used to guide initiation (>0.5-1.0 ug/L) or cessation of Rx (<0.5-1.0 ug/L or decrease of >50-90% of previous level), or both

  • Meta-analysis of 15 studies looking at short term mortality as primary outcome, and length of therapy as secondary outcome

  • Use of procalcitonin to guide cessation of Rx resulted in decreased risk ratio for primary outcome (mortality, 0.87) and decreased Rx duration by 1.26 days

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